Identifiers
Functions
Reported endpoints by species, route and conditions
| Endpoint | Species | Route | Reported value |
|---|---|---|---|
| NOAEL | Rabbit | Oral | NOAELs and irritation data across multiple polyolefins including hydrogenated polyisobutene and polydecene derivatives; no treatment-related adverse effects observed in several oral repetitive-dose studies; minimal to mild dermal irritation in 100% hydrogenated polyisobutene; some agents showed minimal/slightly irritating to rabbit skin/eye in specific formulations. [CIR Safety Assessment (Safety Assessment of Polyene Group as Used in Cosmetics)] |
| LD50 | Rat | Oral | LD50 > 2000 mg/kg (oral) in rats; no details provided beyond that value |
| LD50 | Rat | LD50 intraperitoneal in rat: > 110 gm/kg |