Last 5 years1,158 documents Updated 7 Aug

Protein design and engineering using AI

Overview · What matters in this field right now?

Research

What is being built

Documents by area

  • 393
  • 321
  • 270
  • 142
  • 59

What's new · What is newest in this field?

Newest in innovation

Engineered transposases with improved excision and integration activities and methods of use thereof Patent · Meristem Lipase mutants expressed in Pichia pastoris and their applications Patent · Zhejiang Ronrey Technology Antimicrobial peptides for bookbinding constructed based on machine learning model algorithms and their applications Patent · China Pharmaceutical University A Deep Learning-Assisted Structural Remodeling Design and Dual-Substrate Co-screening Method for Directed Evolution of Lipases Patent · Nanjing Tech University A De novo design method for uracil-DNA glycosylation enzymes based on physical priors and deep learning Patent · Chinese Academy of Agricultural Sciences

Newest in the market

Property guidance for protein sequence generative models with ProteinGuide | Nature Biotechnology News · www.nature.com Frontiers | Artificial intelligence in peptide cancer vaccine design: from neoantigen discovery to immunogenicity prediction News · www.frontiersin.org AI-redesigned starting points and outcomes enhance protein evolution | Nature News · www.nature.com Mind the gap: An embedding guide to safely travel in sequence space | PLOS Computational Biology News · journals.plos.org Zero-shot design of drug-binding proteins via neural iterative selection−expansion | Nature News · www.nature.com

Research · What is being built?

Where the work is growing

Dot size: documents that year
Where the work is growing
Area2021 2022 2023 2024 2025 2026 so farTotal
392
314
269
141
56

What problems are they working on?

Size and shade: documents

Largest 15 of 76 problems

Latest in innovation

Engineered transposases with improved excision and integration activities and methods of use thereof Patent · Meristem Lipase mutants expressed in Pichia pastoris and their applications Patent · Zhejiang Ronrey Technology Antimicrobial peptides for bookbinding constructed based on machine learning model algorithms and their applications Patent · China Pharmaceutical University A Deep Learning-Assisted Structural Remodeling Design and Dual-Substrate Co-screening Method for Directed Evolution of Lipases Patent · Nanjing Tech University A De novo design method for uracil-DNA glycosylation enzymes based on physical priors and deep learning Patent · Chinese Academy of Agricultural Sciences

Market · What is reaching the market?

Latest in the market

Property guidance for protein sequence generative models with ProteinGuide | Nature Biotechnology News · www.nature.com Frontiers | Artificial intelligence in peptide cancer vaccine design: from neoantigen discovery to immunogenicity prediction News · www.frontiersin.org AI-redesigned starting points and outcomes enhance protein evolution | Nature News · www.nature.com Mind the gap: An embedding guide to safely travel in sequence space | PLOS Computational Biology News · journals.plos.org Zero-shot design of drug-binding proteins via neural iterative selection−expansion | Nature News · www.nature.com

Strategy · Where is the money and effort going?

How far along each area is

Innovation Market A year ago
How far along each area is
On its way to market
On its way to market
On its way to market
On its way to market
On its way to market

Money, launches and partners

Partnerships

Genetic engineering of proteins and protein design methods Patent · Massachusetts Institute of Technology, Brigham & Women's Hospital, Beth Israel Deaconess Medical Center · AI-generated nucleases with gene-editing capabilities and their applications Patent · Western Science City, Southwest University · Therapeutic peptides and methods of peptide design Patent · Wisconsin Alumni Research Foundation, University of Illinois Chicago · A method for modifying the hydrolytic performance of lipases and a mutant based on stability constraints and channel dynamic conformation analysis. Patent · Nanjing Tech University, Future Food Research Institute · Methods for screening antibody fc regions Patent · ETH Zurich, University of Waikato · How to create libraries using machine learning Patent · Tohoku University, AIST, University of Tokyo · Model for predicting high-affinity mutation site of antibody, and construction method therefor and use thereof Patent · Biointron Biological, Shanghai Baiying Biotechnology ·

New to this radar

AI-generated nucleases with gene-editing capabilities and their applications Patent · Southwest University, Western Science City · Systems and methods for protein design Patent · Profluent Bio · Epitope prediction via a learned genotype network across class ii mhc alleles Patent · Seattle Project · Screening methods for antimicrobial peptides from deep-sea cold seeps, antimicrobial peptides, their preparation methods, and applications. Patent · Third Institute of Oceanography · Method, system, and computer-accessible medium for modifying and/or redesigning peptide-centric chimeric antigen receptors (pc-cars) against novel peptide antigens Patent · Qichen Tang, Yarmarkovich Mark, Clarke Michael · Machine Methods To Determine Neoepitope Payload Toxicity Patent · Nantbio · Methods, systems, and compositions of generating and analyzing polypeptide libraries Patent · Protillion Biosciences · Engineered scaffold proteins Patent · Monod Bio · Neoantigen identification for t-cell therapy Patent · Seattle Project Company ·

Who bets where · Who is shaping this field?

Data · The evidence behind this radar

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