Calcium Caseinate is a milk protein derived from casein, the primary protein found in cow’s milk. It is commonly used in various cosmetic formulations due to its emulsifying and stabilizing properties. As a water-soluble ingredient, Calcium Caseinate helps to improve the texture and consistency of products, making it ideal for creams, lotions, and other skincare formulations.
Additionally, it is known for its ability to retain moisture, contributing to the hydration of the skin. Its biocompatibility and nutritional profile also make it a valuable component in formulations aimed at enhancing skin health and appearance.
CAS Number: 9005-43-0
Molecular Formula: Y43
Uses of Calcium Caseinate in Cosmetics
Functional role in cosmetics:
- Calcium Caseinate is used as a skin conditioning and bulking agent in cosmetics.
Cosmetic Products Containing Calcium Caseinate
Recent products using Calcium Caseinate in their cosmetic formulations
- Holy land Lactolan Peeling Cream
- Elemis Skin Nourishing Milk Bath
- Elemis Pro-Radiance Hand And Nail Cream
- Elemis Deep Cleanse Facial Wash
- Elemis Sensitive Cleansing Wash
Top companies using Calcium Caseinate in their cosmetic products
- Holy Land
- Elemis
Regulatory Considerations for Using Calcium Caseinate in Cosmetic Formulations
Few regulatory considerations are to be taken into account before using Calcium Caseinate as an ingredient. Given below is the list of those regulations:
New Zealand EPA Inventory of Chemical Status: Caseins, calcium complexes do not have individual approval but may be used as components in products covered by a group standard. They are not approved for use as chemicals in their own right.
The Australian Inventory of Industrial Chemicals: Listed as Caseins, calcium complexes in the Australian Inventory of Industrial Chemicals.
Alternatives of Calcium Caseinate and Comparative Analysis
Given below is the list of alternative ingredients that can be used in place of Calcium Caseinate in cosmetic formulations:
- Sodium Caseinate
- Hydrolyzed Casein
- Soy Protein Isolate
- Hydrolyzed Wheat Protein
- Collagen Peptides
Comparative analysis of Calcium Caseinate alternative ingredients:
| Ingredients | Strengths | Limitations | Efficacy | Cost | Stability | Compatibility | Safety |
| Sodium Caseinate | Higher water solubility than calcium caseinate, improving formulation clarity Excellent emulsifying and stabilizing properties Good skin conditioning and film-forming abilities | Higher sodium content may be a concern in some formulations Less calcium content compared to calcium caseinate | High as emulsifier, stabilizer, and skin conditioner | Moderate | High (stable in neutral to slightly acidic pH) | Good with aqueous and emulsion systems | Generally recognized as safe and non-irritating |
| Hydrolyzed Casein | Smaller peptides improve skin penetration and conditioning Good moisturizing and film-forming properties Enhances hair conditioning and softness | May have less thickening and bulking effect compared to intact caseinates Potential allergen for milk-sensitive individuals | Moderate to high for skin and hair conditioning | Moderate to high | Moderate | Compatible with most cosmetic bases | Generally safe but watch for milk allergies |
| Soy Protein Isolate | Plant-based alternative with good film-forming and moisturizing properties Rich in amino acids beneficial for skin and hair Suitable for vegan and allergen-conscious formulations | Different protein structure may affect texture and stability Potential allergen for soy-sensitive individuals | Moderate as skin and hair conditioner | Moderate | Moderate | Good in aqueous and emulsion systems | Generally safe; potential soy allergen |
| Hydrolyzed Wheat Protein | Improves skin hydration and elasticity Enhances hair strength, shine, and manageability Good film-forming and moisturizing agent | May cause sensitivity in gluten-intolerant individuals Less bulking and thickening effect compared to caseinates | Moderate for skin and hair conditioning | Moderate | High | Compatible with most cosmetic formulations | Generally safe; caution for gluten sensitivity |
| Collagen Peptides | Supports skin elasticity and hydration Good film-forming and moisturizing properties Widely used in anti-aging and skin repair products | Animal-derived, not suitable for vegan formulations May have limited thickening or bulking effect | High for skin conditioning and anti-aging | High | Moderate | Good in aqueous and emulsion systems | Generally safe; watch for animal protein sensitivities |
How Calcium Caseinate Works in Formulations
Calcium Caseinate is a water-soluble protein commonly used in cosmetics for its skin-conditioning, moisturizing, and film-forming properties. It helps improve hydration, strengthen hair, and enhance the texture of skin and hair in various personal care products.
Ideal Concentration and Benefits in Different Formulations
Moisturizers and Creams
Calcium Caseinate is often included in creams and lotions to provide skin barrier support and improve hydration.
- Concentration: 0.5%–3%
- Benefit: Forms a protective film on the skin, helping to minimize moisture loss. Ideal for hydrating skin care products and moisturizers, especially for dry skin.
Hair Care Products (e.g., Conditioners, Masks)
In hair conditioners and masks, Calcium Caseinate helps strengthen hair and improve moisture retention.
- Concentration: Typically used in concentrations below 5%
- Benefit: Enhances softness and manageability, especially in dry or damaged hair. Ideal for dry hair care products, improving moisture retention and hair texture.
Facial Masks and Anti-Aging Products
Calcium Caseinate is incorporated into facial masks and anti-aging products to provide a firming and moisturizing effect.
- Concentration: 0.2% to 2.7%
- Benefit: Forms a conditioning layer that enhances hydration and contributes to smoother skin.
Compatibility with Other Ingredients
Water-soluble and compatible with most cosmetic ingredients, making it easy to incorporate into various formulations. Sensitive to high heat—requires low-temperature processing to prevent denaturation. Not suitable for vegan or dairy-sensitive consumers; clear labeling is recommended.
Stability and Shelf Life
Calcium Caseinate is stable under standard storage conditions, ensuring reliable performance in formulations.
- Shelf life: 12–24 months
- Best storage: Store in airtight containers, away from moisture and light to maintain its efficacy. Use sealed jars or other airtight packaging to minimize exposure to air and humidity, which could lead to degradation.
Formulation Challenges and Troubleshooting
Calcium Caseinate presents several formulation challenges due to its proteinaceous nature and sensitivity to certain conditions:
Heat Sensitivity
Calcium Caseinate may denature at high temperatures, affecting its functionality in formulations.
Solution: Use low-temperature processing techniques to maintain its stability and efficacy.
Allergen Concerns
As a milk-derived ingredient, Calcium Caseinate may pose allergen risks for lactose-intolerant or dairy-allergic individuals.
Solution: Clearly label products containing Calcium Caseinate and provide warnings for sensitive users.
Texture and Solubility
Calcium Caseinate may form clumps if not properly dissolved during formulation.
Solution: Use gentle agitation during mixing and ensure even dispersion to avoid clumping.
Packaging Compatibility
Calcium Caseinate is hygroscopic and may absorb moisture, leading to degradation over time.
Solution: Use moisture-resistant packaging such as HDPE or glass containers to maintain product stability.
Regulatory Compliance
Ensure compliance with local regulations regarding the use of milk-derived ingredients in cosmetics and proper allergen labeling.
Solution: Consult regulatory guidelines for specific applications and regions.
Is Calcium Caseinate Safe in Cosmetics?
Safety reports for Calcium Caseinate are given below:
- Safety Assessment of Bovine Milk Proteins and Protein Derivatives as Used in Cosmetics. Download PDF
Environmental and Sustainability Impact
Calcium Caseinate is a protein derived from casein, a milk-based ingredient. In cosmetics, it is primarily used as a moisturizing and conditioning agent. Its use raises environmental and sustainability considerations:
Environmental Impact
- Water Pollution: Calcium Caseinate is biodegradable and poses minimal risk to aquatic organisms. However, improper disposal in high concentrations may contribute to localized water contamination.
- Carbon Footprint: The production of Calcium Caseinate involves dairy farming and processing, which contribute to greenhouse gas emissions, especially methane, from livestock.
Sustainability
The sustainability of Calcium Caseinate depends on its sourcing—primarily dairy farming—and production methods.
- Raw Materials: Derived from milk, Calcium Caseinate relies on dairy farming, which may raise concerns about animal welfare, water usage, and greenhouse gas emissions. Transitioning to organic or sustainably farmed sources can mitigate these issues.
- Energy Use: Manufacturing involves processes like filtration and drying, which require moderate energy input. Cleaner energy sources and efficient processing methods could reduce its environmental footprint.
- End-of-Life Impact: Calcium Caseinate is biodegradable and breaks down naturally in the environment, posing minimal long-term ecological risks.
Biodegradability and Toxicity
Calcium Caseinate is biodegradable and non-toxic to the environment under normal use conditions.
Ammonia Toxicity: Not applicable. Calcium Caseinate does not release ammonia or harmful byproducts during decomposition.
Eco-Friendly Alternatives
For those seeking non-animal-derived or more sustainable options, the following alternatives may be used:
- Hydrolyzed Soy Protein: A plant-based alternative that provides similar conditioning and moisturizing effects.
- Hydrolyzed Wheat Protein: Another plant-derived option with comparable benefits and lower environmental impact.
- Silk Amino Acids: A sustainable option derived from silk fibers, offering conditioning properties similar to Calcium Caseinate.
Calcium Caseinate Side Effects
Calcium Caseinate is derived from milk proteins and widely used as a skin and hair conditioning agent in cosmetics. It is generally recognized as safe (GRAS) and has low potential for irritation or sensitization. Studies show no mutagenic or carcinogenic effects, and it is considered safe at concentrations up to 2% in leave-on products. Daily exposures from food use far exceed those from cosmetics, minimizing systemic risk.
Symptoms
- Eye Exposure: May cause mild irritation.
- Skin Exposure: Can lead to mild irritation in sensitive individuals.
- Ingestion Exposure: No adverse effects expected under normal use.
- Inhalation Exposure: May cause slight respiratory tract irritation.
Interactions
Calcium Caseinate has no reported interactions with other cosmetic ingredients. Studies indicate it is safe for use in cosmetics at concentrations up to 2% in leave-on products.
Target Organs
Primary target organs include the skin and respiratory system.
Toxicity Data
No significant toxicity data available for Calcium Caseinate in cosmetic applications. It is considered non-hazardous under normal usage conditions.
Adverse Effects
Prolonged exposure may cause mild irritation in individuals with sensitive skin or allergies to milk proteins.
Exposure Routes
Dermal exposure is the primary route of contact with Calcium Caseinate in cosmetics. Inhalation exposure is possible with spray formulations.
Antidote and Emergency Treatment
- Immediate First Aid: For eye contact, rinse thoroughly with water. In cases of skin irritation, wash the area with soap and water. If inhaled, move to fresh air.
- Basic Treatment: Treat skin irritation with emollients if needed. Ensure clear airways for inhalation exposure.
- Advanced Treatment: No advanced treatment required under normal circumstances due to low toxicity.
Properties of Calcium Caseinate
Chemical Identifiers
| EC Number | 618-418-2 |
| InChIKey | XHNWPXNQNBLSAW-UHFFFAOYSA-N |
| IUPAC Name | yttrium |
| InChI | InChI=1S/43Y |
Physical and Chemical Properties
Calcium Caseinate is a milk protein derived from casein, typically formed by the precipitation of casein with calcium ions. It appears as a white to off-white powder and is soluble in water, forming a colloidal solution. This protein exhibits a high nutritional value, containing essential amino acids, and has a molecular weight ranging from 20,000 to 100,000 Da.
Calcium Caseinate is stable under heat and has emulsifying and thickening properties, making it useful in various food applications. Its calcium content contributes to bone health, while its low fat content makes it a popular choice in dietary supplements and protein-enriched products.
Structural Properties
The properties provided describe Calcium Caseinate, a compound with a molecular weight of approximately 3823 g/mol. It consists of three heavy atoms and contains 43 covalently bonded units. The structure is canonicalized, meaning it has a stable, standard form.
The compound is not involved in hydrogen bonding (neither donor nor acceptor). Additionally, the surface area and bond stereochemistry suggest a straightforward, non-complex structure with no rotating bonds or undefined atomic arrangements.
| Property | Value |
| Complexity | 0 |
| Exact Mass | 3822.9510 g/mol |
| Formal Charge | 0 |
| Heavy Atom Count | 3 |
| Molecular Weight | 3822.951 g/mol |
| Monoisotopic Mass | 3822.9510 g/mol |
| Isotope Atom Count | 0 |
| Rotatable Bond Count | 0 |
| Compound Is Canonicalized | Yes |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Covalently-Bonded Unit Count | 43 |
| Topological Polar Surface Area | 0 Ų |
| Defined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
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