Identifiers
Functions
Key organizations include Neuroreserve Inc (US12636281B2) claiming dietary supplements for brain health and neurodegenerative disease mitigation, Epigenics GmbH (DE202025004173U1) claiming sleep-wake rhythm improvement, and individual inventors like Pustovoit Vasily Igorevich (RU2866905C1) and Kim Min Suck (KR102973867B1) claiming anti-stress and multi-component health supplement compositions. These claims focus on synergistic combinations with theanine, tryptophan, melatonin, GABA, and polyphenols, positioning magnesium bisglycinate as a versatile mineral for neurological and stress-related benefits.
Monthly patent filings by domain
Recent patents address formulation stability and bioavailability challenges for magnesium bisglycinate in complex matrices. RU2866905C1 tackles moisture sensitivity and shelf-life by microencapsulating the mineral in a prebiotic shell and specifying low water activity (≤0.35) and moisture (≤4.5%). KR102973867B1 integrates magnesium bisglycinate into a multi-component granulation process alongside nanoemulsions and liposomes, implying a need for physical compatibility with diverse actives. US12636281B2 and DE202025004173U1 focus on delivering magnesium in combination with polyphenols, amino acids, and sleep aids without specifying stability, but the dosage forms suggest a need for consistent release and absorption.
Recent patents expand magnesium bisglycinate from a simple mineral supplement to a functional component in targeted health applications. In DE202025004173U1, it is positioned as a bioavailable magnesium source for sleep-wake rhythm improvement, paired with melatonin and GABA. US12636281B2 uses it as a 'magnesium derivative' in brain health and neurodegenerative disease formulations, alongside polyphenols and omega-3s. RU2866905C1 casts it as an active anti-stress and adaptogenic agent with L-theanine and L-tryptophan. These shifts indicate a move toward condition-specific, multi-ingredient formulations where magnesium bisglycinate supports neurological and stress-related outcomes rather than general mineral repletion.
Emerging strategies include powdered sachets for on-the-go anti-stress drinks (RU2866905C1), multi-ingredient health supplements with granulation and nanoemulsion/liposome technology (KR102973867B1), and dietary supplements for brain health or sleep support (US12636281B2, DE202025004173U1). Formulation approaches emphasize microencapsulation with prebiotic fibers, controlled water activity, and combination with adaptogens, amino acids, polyphenols, and melatonin. These strategies target convenience, stability, and synergistic efficacy, often in food-beverage and pharmaceutical crossover formats.
Evidence-backed white space exists in developing magnesium bisglycinate formulations that address specific technical challenges not fully covered in current patents. For example, while RU2866905C1 specifies microencapsulation for stability, there is no disclosed data on long-term stability or bioavailability enhancement. Similarly, KR102973867B1 includes magnesium bisglycinate in a granulation process but does not detail its interaction with nanoemulsions or liposomes. Further research could explore optimized release profiles, taste-masking, or targeted delivery for brain health, building on the claimed combinations but with more rigorous physicochemical characterization.