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Last updated January 31, 2026
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Syngenta Research Landscape: Recent R&D and Innovation Focus Areas

This landscape reveals what Syngenta is actively researching on recently. It organizes signals from patents into clusters of real scientific and technical questions being explored, showing where Syngenta is repeatedly investing effort, building knowledge, and reducing uncertainty. The result is a forward-looking view of strategic intent , often visible months or years before it appears in products, partnerships, or financial disclosures of Syngenta.

What are Syngenta's key R&D focus areas?

Metarylpicoxamid formulation chemistry

(3)problems

Pathogen resistance and chemical volatility reduce crop protection efficacy, which is mitigated through the precise ratio control of specific picolinamide and phenylpyrrole active ingredients. This targeted chemical blending stabilizes the fungicidal action across diverse environmental conditions.

Simultaneous haploid induction editing

(3)problems

Conventional breeding cycles are slow and costly due to multi-generational stabilization requirements. This lever integrates haploid induction with simultaneous genomic modification to achieve immediate homozygous trait fixation.

Substituted azole heterocyclic scaffolds

(2)problems

Uncontrolled weed competition reduces crop yields and increases operational costs. These innovations engineer specific imidazole, pyrazole, and thiazole molecular structures to ensure targeted herbicidal efficacy.

Inbred corn germplasm lines

(2)problems

Genetic variability in commercial maize production creates yield instability and susceptibility to environmental stressors. Precise control over parental inbred lines ensures phenotypic uniformity and heterotic performance in hybrid offspring.

Androgenesis haploid induction compositions

(3)problems

Slow breeding cycles and genetic heterozygosity delay commercial seed readiness. These chemical and biological triggers force paternal genome inheritance to accelerate the production of pure homozygous lines.

Soybean germplasm genetic architecture

(3)problems

Yield instability and disease susceptibility in commercial crops create significant financial risk for growers. These innovations stabilize performance through the engineering of specific proprietary genetic markers and trait combinations.

Axillary meristem cytotype modulation

(4)problems

Low T1 event diversity and poor transformability limit the speed of trait development. These methods engineer the cytotype transfer process to increase genetic variation and stabilization in sunflower lineages.

Synergistic fungicidal chemical formulations

(2)problems

Pathogen resistance and off-target toxicity increase crop loss risks, which these compositions mitigate through precise active ingredient ratios. Optimizing chemical synergy ensures efficacy at lower dosage rates to maintain regulatory compliance.

Picolinamide and isonicotinamide scaffolds

(3)problems

Pathogen resistance and non-specific toxicity increase crop loss and environmental risk. These derivatives utilize specific isonicotinamide structural modifications to achieve targeted antimicrobial potency.

Flavonoid biosynthetic pathway modulation

(4)problems

Inconsistent pollen viability leads to crop failure and reduced yield stability. Engineering specific metabolic precursors ensures reproductive success and genetic transmission.

Synthetic herbicidal molecular scaffolds

(3)problems

Uncontrolled weed proliferation reduces crop yields and increases operational overhead. These innovations engineer specific molecular structures to selectively disrupt plant metabolic pathways.

Germplasm genetic architecture

(2)problems

Inconsistent crop performance across diverse environments leads to yield instability and financial loss. These innovations utilize specific genetic lineages to ensure predictable phenotypic expression and environmental resilience.

Cas exonuclease fusion proteins

(4)problems

Random genomic integration leads to unpredictable phenotypes and low breeding efficiency, which is mitigated by engineering site-specific cleavage and inversion mechanisms. Precise control over insertion sites ensures stable trait expression and reduces the cost of screening non-viable cell lines.

Transgenic bt protein expression systems

(4)problems

Uncontrolled pest proliferation destroys crop yields and increases chemical dependency. These innovations engineer specific fungal spore delivery systems and antibody-mediated targeting to provide biological pest suppression.

Synergistic multicomponent fungicidal formulations

(2)problems

Pathogen resistance and crop loss drive up agricultural costs, which these compositions mitigate through specific chemical ratios that enhance biocidal efficacy. Precise control of active ingredient concentrations prevents fungal proliferation while minimizing environmental toxicity.

Synthetic quinoline cinnoline scaffolds

(2)problems

Uncontrolled weed growth reduces crop yields and increases labor costs, which these specific chemical structures mitigate through targeted enzymatic inhibition. Engineering the quinolone-pyrimidine linkage provides the precise molecular geometry required to disrupt plant metabolism without harming the primary crop.

Cyanocyclopropyl heteroarene synthesis pathways

(2)problems

Inefficient multi-step synthesis of substituted heterocycles increases manufacturing costs and reduces purity. These processes utilize specific regioselective substitution patterns to streamline the production of complex pharmaceutical intermediates.

Pyridine and trifluoroethanone synthetic pathways

(3)problems

Inefficient substitution patterns in aromatic precursors lead to low yields and costly purification steps. These processes utilize specific catalytic pathways to control regioselectivity and functional group placement in complex intermediates.

Variable-rate manifold assembly

(3)problems

Manual synthesis of agricultural compounds is too slow and inconsistent for rapid product development. This lever utilizes parallelized electrochemical control to accelerate the discovery and production of precise pesticide formulations.

Automated seed treatment loading architecture

(3)problems

Inconsistent chemical application and dust abrasion during sowing lead to crop loss and environmental fines. These innovations utilize real-time quantitative sensing and mechanical containment to ensure precise dosage and structural integrity.

Thermally stabilized agrochemical matrices

(4)problems

Inconsistent bioavailability and poor shelf stability of active ingredients lead to wasted chemical application and reduced crop protection. These innovations engineer the physical state and carrier matrix to ensure precise delivery and environmental resilience.

Cyclopropene cellulose nanocrystal stabilization

(3)problems

Emulsion instability and phase separation lead to inconsistent product performance. These innovations utilize cellulose nanocrystals to engineer stable interfacial boundaries that prevent droplet coalescence.

Coleopteran specific dsrna interference constructs

(2)problems

Crop destruction by beetle larvae causes significant yield loss and chemical runoff risks. These innovations utilize sequence-specific genetic interference to provide targeted pest lethality without affecting non-target species.

Asymmetric isoxazoline synthesis catalysis

(5)problems

Uncontrolled chirality in small molecule synthesis leads to low pharmacological potency and high purification costs. These innovations utilize specific catalytic pathways to ensure precise enantiomeric and diastereomeric enrichment.

Synthetic small molecule herbicides

(2)problems

Uncontrolled weed proliferation reduces crop yields and increases operational costs. These innovations engineer specific molecular structures to achieve targeted phytotoxic activity.

Substituted thiophenyl uracil derivatives

(3)problems

Uncontrolled weed proliferation reduces crop yields and increases harvesting costs. These innovations utilize specific benzamide substitutions to provide selective herbicidal activity and prevent crop loss.

Synergistic herbicidal active ratios

(2)problems

Uncontrolled weed resistance and crop phytotoxicity increase operational costs and reduce yields. These innovations engineer specific chemical ratios and adjuvant systems to enhance herbicidal efficacy while maintaining crop safety.

Recombinant cry protein variants

(3)problems

Crop yield loss from pest resistance increases operational costs and chemical dependency. These innovations modify specific protein structures to maintain high-affinity binding and toxicity against resistant insect populations.

Nematocidal chemical composition control

(2)problems

Indiscriminate pest damage reduces soybean yields and increases chemical overhead costs. Targeted application of specific aryloxyphenoxypropionate esters provides selective metabolic disruption to mitigate crop loss.

Ppo inhibitor synergistic herbicidal formulations

(3)problems

Herbicide resistance in sugar cane cultivation increases crop loss and management costs. These methods utilize specific chemical combinations to restore efficacy against PPO-resistant weed populations.

Germplasm allelic trait introgression

(3)problems

Yield volatility and pathogen susceptibility threaten crop profitability, which is mitigated through the engineering of proprietary soybean genetic profiles. Precise control over the germplasm sequence ensures consistent agronomic performance and trait stability.

Substituted cyclic amine scaffolds

(4)problems

Pest resistance and off-target toxicity increase crop loss risks, which are mitigated through the engineering of specific heterocyclic amine and thioamide molecular architectures. These precise chemical substitutions enhance binding affinity to target receptors while reducing environmental degradation.

Trinexapac-ethyl microemulsion phase stabilization

(2)problems

Active ingredient degradation and poor bioavailability in aqueous environments lead to inconsistent crop growth regulation. These formulations utilize specific surfactant-solvent ratios to maintain thermodynamic stability and prevent crystallization.

Phaseolus vulgaris germplasm lineage

(3)problems

Yield instability and disease susceptibility in legume crops threaten commercial harvest predictability. This specific genetic profile standardizes phenotypic expression to ensure consistent crop performance.

Isoxazoline and loline alkaloid synergists

(2)problems

Pest resistance and metabolic breakdown reduce the efficacy of standard alkaloid treatments. These specific chemical scaffolds stabilize the formulation to ensure lethal dose delivery through synergistic metabolic inhibition.

Fused imidazopyrazine and benzimidazole scaffolds

(3)problems

Off-target binding and poor metabolic stability in kinase inhibition lead to high drug failure rates. These specific heterocyclic scaffolds are engineered to optimize binding affinity and pharmacokinetic profiles.

Pyridinium derivative chemical scaffolds

(3)problems

Uncontrolled weed resistance and non-target toxicity increase crop loss risks. These innovations engineer specific nitrogen-heterocycle substitutions to modulate herbicidal potency and selectivity.

Synergistic fungicidal active formulations

(2)problems

Crop loss from fungal pathogens creates massive yield instability and financial risk. These innovations engineer specific chemical synergies and molecular structures to ensure targeted fungal eradication.

Halogenated pyrazole carboxamide scaffolds

(2)problems

Pathogen resistance and non-target toxicity increase crop loss risks, which these specific chemical scaffolds mitigate through targeted enzymatic inhibition. Precise structural modification of the pyrazole ring enhances potency while reducing environmental persistence.

Sulfur-substituted tetracyclic heterocyclic derivatives

(2)problems

Uncontrolled pest resistance and off-target toxicity increase crop loss risks, which are mitigated by engineering specific sulfur-containing substituents onto heterocyclic scaffolds to modulate bioactivity. This chemical modification enhances metabolic stability and binding affinity for targeted pest control.

Fused bicyclic heteroaromatic amino scaffolds

(2)problems

Uncontrolled pest resistance and non-target toxicity increase crop loss risks. These innovations engineer specific heterocyclic core geometries to enhance binding affinity and metabolic stability.

Vegetative propagule encapsulation systems

(3)problems

Manual propagation of sugar cane seedlings is labor-intensive and prone to contamination, which is mitigated through controlled environment tank systems. These bioreactors scale production volume while maintaining sterile conditions to ensure high-yield transplant units.

Germplasm pathogen resistance traits

(2)problems

Uncontrolled crop loss from disease outbreaks threatens yield stability and increases pesticide dependency. These innovations engineer specific genetic loci to provide durable biological resistance within Cucurbita and Brassica lineages.

Antifungal phytopathogenic chemical agents

(3)problems

Undetected soil-borne pathogens lead to rapid crop loss and excessive fungicide application. These innovations utilize specific primer sets for rapid isothermal amplification to enable early-stage pathogen detection and targeted intervention.

Spiropidion tetramic acid derivatives

(3)problems

Crop yield loss from resistant pest populations requires precise chemical intervention. These innovations utilize specific tetramic acid derivatives and aryloxyphenoxypropionate esters to disrupt lipid biosynthesis and metabolic pathways.

Soybean aphid resistance loci

(2)problems

Pathogen-driven yield loss creates significant economic risk for growers, which is mitigated through the targeted engineering of specific genetic loci to enhance innate immunity. Precise manipulation of these genomic regions allows for the development of cultivars that maintain high productivity under high disease pressure.

Cyclopropyl and azole amide scaffolds

(4)problems

Crop loss from pest resistance and environmental degradation increases operational risk, which is mitigated through the synthesis of specific heterocyclic amide structures to ensure targeted neurotoxic or metabolic disruption in parasites. These proprietary molecular frameworks provide the necessary chemical stability and binding affinity to protect propagation materials where generic pesticides fail.

Trifluoromethylpyridine insecticidal bait formulations

(2)problems

Crop and livestock losses occur when pests survive initial contact and continue feeding. These formulations engineer specific chemical structures to trigger immediate physiological inhibition and blood-feed cessation.

Substituted pyridone herbicidal scaffolds

(1)problems

Uncontrolled weed resistance and non-selective toxicity threaten crop yields. Engineering specific functional groups onto the pyridone core enables precise enzymatic inhibition in target plant species.

Heterocyclic aryl formamidine synthesis

(2)problems

Unstable chemical intermediates in microbiocide production lead to low yields and high waste. These innovations engineer specific reaction sequences to stabilize the oxadiazole ring formation for industrial scale-up.

Oxadiazole derivative molecular scaffolds

(3)problems

Phytopathogenic infestations lead to significant crop yield loss and chemical resistance. These innovations engineer specific oxadiazole molecular structures to achieve targeted metabolic disruption in microorganisms.

Heterobicyclic microbicidal derivatives

(4)problems

Pathogen resistance and chemical instability reduce the efficacy of traditional crop protection agents. These derivatives utilize a specific heterocyclic core to maintain structural integrity and target-site binding.

Oxadiazole derivative molecular scaffolds

(3)problems

Pathogen resistance and off-target toxicity in crop protection increase operational costs. These specific heterocyclic derivatives provide a novel chemical lever for targeted enzymatic inhibition in microbicides.

Alkynylphenyl substituted cyclic diones

(3)problems

Resistant weed populations reduce crop yields and increase operational costs, which this specific spirocyclic molecular architecture mitigates through targeted enzymatic inhibition. Engineering the azaspiro-dione core allows for precise chemical selectivity to overcome existing herbicide resistance patterns.

Herbicide active ingredient delivery matrix

(3)problems

Uncontrolled active ingredient leaching leads to environmental runoff and reduced efficacy. These innovations engineer the chemical matrix to stabilize delivery and extend weed suppression windows.

Synthetic plant regulatory sequences

(3)problems

Unpredictable transgene expression levels lead to poor phenotypic stability and yield loss. These innovations engineer specific DNA regulatory elements to ensure precise spatiotemporal control of protein production.

Fludioxonil postharvest fungicide formulation

(1)problems

Post-harvest fungal decay causes significant inventory loss during storage and transport. Precise chemical stabilization of fludioxonil ensures consistent active ingredient delivery to prevent crop spoilage.

Diamide resistant pest control compounds

(3)problems

Targeted pest populations have evolved metabolic resistance to standard diamide insecticides, leading to crop loss and increased chemical application costs. These molecular structures bypass existing resistance mechanisms to restore efficacy in field applications.

Specific germplasm genetic introgressions

(4)problems

Unpredictable phenotypic expression in cucurbit and solanaceous crops risks commercial yield loss. These innovations secure proprietary genetic sequences to ensure stable inheritance of desirable agronomic traits.

Specific cultivar genetic profiles

(2)problems

Unpredictable phenotypic expression in commercial lettuce crops leads to inconsistent yields and disease vulnerability. These proprietary genetic lineages provide standardized resistance and growth traits to ensure harvest reliability.

Quinoline thiocarboxamide molecular scaffolds

(2)problems

Pathogen resistance and chemical instability in industrial biocides lead to crop loss and product spoilage. These innovations engineer specific heterocyclic quinoline scaffolds to maintain antimicrobial potency and structural stability.

Thiazole derived microbiocidal compounds

(2)problems

Crop loss from phytopathogenic infestation threatens agricultural yield and profitability. These innovations engineer specific thiazole-based chemical structures to disrupt microbial metabolic pathways and prevent plant infection.

6-anilino purine derivative formulations

(2)problems

Unpredictable crop metabolic responses to environmental stress lead to yield instability, which is mitigated through the engineering of specific plant-derived secondary metabolites. Standardizing these bioactive concentrations ensures consistent physiological priming and nutrient uptake across varying soil conditions.

Synthetic phytohormone analog formulations

(1)problems

Unpredictable crop maturation cycles and environmental stress lead to significant yield volatility. Engineering specific hormonal pathways through chemical regulators stabilizes biomass accumulation and harvest timing.

Tetrahydroisoquinoline quinolyl derivative synthesis

(2)problems

Pathogen resistance and chemical instability in traditional biocides lead to crop loss and high application costs. These innovations utilize specific tetrahydroisoquinoline derivatives to provide targeted antimicrobial activity and enhanced molecular stability.

Polyurea microencapsulation shell wall

(1)problems

Active ingredient degradation and non-target toxicity increase operational costs and environmental risk. Engineering the polymer shell wall thickness and permeability controls the release rate to extend efficacy.

1/135 fungicide compound formulation

(1)problems

Crop loss from fungal infestation threatens yield stability and food security. These innovations engineer specific chemical structures and delivery compositions to inhibit microorganism proliferation on host plants.

Germplasm specific phenotypic trait selection

(4)problems

Genetic variability in ornamental crops leads to inconsistent commercial traits and yield loss. These innovations secure phenotypic stability through the engineering of specific stable cultivars.

Pyrazolidinedione and pyridazinone synthesis pathways

(2)problems

Inefficient multi-step synthesis of complex herbicides increases production costs and chemical waste. These innovations engineer specific heterocyclic ring-closure pathways to improve isomeric purity and yield.

Halogenated heterocyclic microbiocidal compounds

(2)problems

Crop loss from fungal pathogens creates massive yield instability and financial risk. These innovations engineer specific molecular structures to inhibit fungal growth and protect agricultural assets.

Pyrazole alkylation and amidation chemistry

(1)problems

Inefficient chiral separation and low regioselectivity in heterocyclic synthesis drive up active ingredient costs. These innovations utilize enantioselective catalytic pathways to ensure high-purity isomer production.

Interspecific anthocyanin biosynthetic pathway

(2)problems

Genetic variability in ornamental breeding leads to inconsistent floral traits and growth habits. This specific cultivar stabilizes phenotypic expression through controlled asexual reproduction.

Synergistic herbicidal active ratios

(3)problems

Uncontrolled weed growth competes with crop nutrients and reduces harvest yields. These compositions utilize specific pyrimidine chemical structures to achieve targeted metabolic disruption in invasive species.

Pyridine carboxamide molecular scaffolds

(3)problems

Unstable molecular geometries in bioactive compounds lead to rapid metabolic degradation and poor binding affinity. Precise engineering of the four-membered ring carboxamide structure stabilizes the molecular backbone to enhance target selectivity and potency.

Germplasm specific genetic loci

(3)problems

Market volatility in ornamental horticulture stems from unpredictable floral phenotypes and growth habits. This specific genetic lineage secures consistent morphological traits and reproductive stability for commercial scaling.

Chrysanthemum cultivar genetic lineage

(3)problems

Standardized floral morphology and growth habits are unpredictable in wild-type varieties, leading to inconsistent commercial yields. This specific genetic stabilization ensures uniform phenotypic expression for industrial-scale horticulture.

Wheat germplasm genetic loci

(1)problems

Yield instability and disease susceptibility in cereal crops create significant financial risk for growers. These proprietary genetic lineages mitigate these risks through the selection of stable, high-performing phenotypic traits.

Polymorphic and cocrystal phase engineering

(1)problems

Unstable active ingredient phases lead to inconsistent bioavailability and shelf-life degradation. Precise control of the monohydrate crystalline lattice ensures thermodynamic stability and predictable dissolution rates.

Crystalline polymorph phase control

(1)problems

Unpredictable phase transitions during manufacturing compromise drug solubility and shelf-life stability. Precise engineering of specific crystalline lattices ensures consistent bioavailability and regulatory compliance.

Polymeric seed coating formulations

(1)problems

Inconsistent application of protective agents during pre-processing leads to seed degradation and crop loss. These compositions standardize the chemical delivery interface to ensure uniform protection of raw coffee beans.

Exogenous rna interference molecules

(2)problems

Crop loss from pest predation and nucleic acid degradation during transport increases operational costs. These innovations utilize sequence-specific RNA molecules to trigger gene silencing in target organisms while stabilizing the genetic payload.

Inducible bicyclic pesticidal compounds

(2)problems

Off-target toxicity and rapid resistance development in agrochemicals increase crop loss risks. These innovations engineer specific nitrogen-containing ring geometries to ensure high-affinity binding to target enzyme sites.

Validated drought tolerance genetic markers

(2)problems

Unpredictable crop yields under environmental stress lead to significant agricultural revenue loss. These innovations utilize specific genetic probes and markers to identify high-performance germplasm for consistent yield stability.

Ethanol fermentation byproduct nutrient fortification

(1)problems

Nutrient degradation during storage and digestion reduces livestock growth rates and increases waste. These innovations engineer the physical and chemical structure of the feed to ensure precise metabolic uptake.

Transgenic event nucleotide joining sequences

(2)problems

Unintended genetic drift and regulatory non-compliance risk the commercial viability of transgenic crops. These specific nucleotide joining sequences enable precise diagnostic identification and trait stabilization for pest-resistant maize lineages.